Microbiome Sample Preparation: Efficient DNA Extraction and Optional Mechanical Shearing
Understanding microbiomes is an increasing focus of many research programs. Genome sequencing has enabled new knowledge that far exceeds capabilities of traditional microbiology culture-based techniques. Microbiome research is vital to the development of global strategies for dealing with antibiotic resistance, antibiotic development and antibiotic stewardship. In parallel with the success of fecal transplants and prescription probiotics, the demonstration of a radical new approach to infectious disease management is in motion. Empirical observations that a healthy microbiome is protective against disease can be supported by analytical data. Microbiome analysis may become mainstream for managing specific disease states, such as cure vs recurrence of C. difficile infections.