Support and Resources
Search all resources
Ranjan et al. 2012. International Journal of Nanomedicine 7: 3475–85. In this paper, the authors used Covaris AFA technology in the incorporation of peptide-PEG-lipid conjugates into liposomes after the organic solvent evaporation step.
A rapid, standardized protein extraction method using adaptive focused acoustics for identification of mycobacteria by MALDI-ToF MS
Mycobacterial identification using MALDI-ToF MS (MALDI) has been hindered by inadequate extraction methods. Adaptive Focused Acoustics™ uses concentrated ultrasonic energy to achieve cellular disruption. Using this technology, we developed a rapid mycobacterial inactivation/protein extraction method for MALDI- based identification. Agreement for identification to the species level versus conventional identification was stratified by log confidence cut-offs of […]
(Application Notes Publications )
We present an automated, high throughput library construction process for 454 technology. Sample handling errors and cross-contamination are minimized via end-to-end barcoding of plasticware, along with molecular DNA barcoding of constructs. Automation-friendly magnetic bead-based size selection and cleanup steps have been devised, eliminating major bottlenecks and significant sources of error. Using this methodology, one technician […]
(User Manuals )
truXTRAC™ MALDI-TOF Mycobacteria Kit Protocol Part Number 010317
Adaptive Focused Acoustics (AFA) -based DNA extraction and purification from Formalin-Fixed, Paraffin-Embedded (FFPE) Tissue.
It is challenging to monitor the health of transplanted organs, particularly with respect to rejection by the host immune system. Because transplanted organs have genomes that are distinct from the recipient’s genome, we used high throughput shotgun sequencing to develop a universal noninvasive approach to monitoring organ health. We analyzed cell-free DNA circulating in the […]
Down-regulation of the Notch pathway mediated by a γ-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia
γ-Secretase inhibitors (GSIs) block NOTCH receptor cleavage and pathway activation and have been under clinical evaluation for the treatment of malignancies such as T-cell acute lymphoblastic leukaemia (T-ALL). The ability of GSIs to decrease T-ALL cell viability in vitro is a slow process requiring >8 days, however, such treatment durations are not well tolerated in […]
Browse by category
Protocols & User Manuals
Includes protocols, product manuals, data sheets and product inserts.
Includes case studies and application notes.
Citations and References
Includes publications, posters and webinars.
User Support and Software Downloads
Information on software downloads and instrument and application support.
Safety Data Sheets
Safety data sheets for Covaris products.
Frequently Asked Questions (FAQs)
Find commonly asked questions about Covaris products.
Covaris provides tools and technologies to improve pre-analytical sample preparation, enable novel drug formulations, and manage compounds in the drug discovery process.