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Massively parallel sequencing systems continue to improve on data output, while leaving labor-intensive library preparations a potential bottleneck. Efforts are currently under way to relieve the crucial and time-consuming work to prepare DNA for high-throughput sequencing.
Integrated Analysis of Gene Expression, CpG Island Methylation, and Gene Copy Number in Breast Cancer Cells by Deep Sequencing
We used deep sequencing technology to profile the transcriptome, gene copy number, and CpG island methylation status simultaneously in eight commonly used breast cell lines to develop a model for how these genomic features are integrated in estrogen receptor positive (ER+) and negative breast cancer.
Epithelial-mesenchymal transition and FOXA genes during tobacco smoke carcinogen induced transformation of human bronchial epithelial cell
Bersaas, A., Arnoldussen, Y. J., Sjøberg, M., Haugen, A., & Mollerup, S. (2016). Epithelial-mesenchymal transition and FOXA genes during tobacco smoke carcinogen induced transformation of human bronchial epithelial cells. Toxicology in Vitro, 35, 55-65. doi:10.1016/j.tiv.2016.04.012
truXTRAC™ MALDI-TOF MS Protocol Heat-inactivated Preparation Protocol for Mycobacteria Colony Samples and Analysis on the Bruker MALDI Biotyper® MALDI-TOF Mass Spectrometer Document Number: 010324
Maternal whole blood cell miRNA340 is elevated in gestational diabetes and inversely regulated by glucose and insulin
Stirm L, Huypens P, Sass S, et al. Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin. Sci Rep. 2018;8(1):1366. ABSTRACT: The number of pregnancies complicated by gestational diabetes (GDM) is increasing worldwide. To identify novel characteristics of GDM, we studied miRNA profiles of maternal and fetal […]
Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice
The clinical use of mefloquine (MQ) has declined due to dose-related neurological events. Next generation quinoline methanols (NGQMs) that do not accumulate in the central nervous system (CNS) to the same extent may have utility. In this study, CNS levels of NGQMs relative to MQ were measured and an early lead chemotype was identified for […]
FFPE sectionPICK is designed to collect FFPE tissue sections mounted on slides. FFPE sectionPICK and sectionWARMER are designed to be used with Covaris truXTRAC kits for DNA and RNA extraction from FFPE samples.
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Covaris provides tools and technologies to improve pre-analytical sample preparation, enable novel drug formulations, and manage compounds in the drug discovery process.