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A Comparison of Gene Expression Profiles between Glucocorticoid Responder and NonResponder Bovine Trabecular Meshwork Cells Using RNA Sequencing
Bermudez JY, Webber HC, Brown B, Braun TA, Clark AF, Mao W. A Comparison of Gene Expression Profiles between Glucocorticoid Responder and Non-Responder Bovine Trabecular Meshwork Cells Using RNA Sequencing. PLoS ONE. 2017;12(1):e0169671. Abstract: The most common ocular side effect of glucocorticoid (GC) therapy is GC-induced ocular hypertension (OHT) and GC-induced glaucoma (GIG). GC-induced OHT […]
2014 AGBT – Active Deparaffinization Drives Superior Yields, Quality and Sequencing Coverage from FFPE Tissue Samples
Keller MP, Gatti DM, Schueler KL, et al. Genetic Drivers of Pancreatic Islet Function. Genetics. 2018;209(1):335-356. Abstract: The majority of gene loci that have been associated with type 2 diabetes play a role in pancreatic islet function. To evaluate the role of islet gene expression in the etiology of diabetes, we sensitized a genetically diverse […]
Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma
Classic Kaposi sarcoma (KS) is exceedingly rare in children from the Mediterranean Basin, despite the high prevalence of human herpesvirus-8 (HHV-8) infection in this region. We hypothesized that rare single-gene inborn errors of immunity to HHV-8 may underlie classic KS in childhood. We investigated a child with no other unusually severe infectious or tumoral phenotype […]
We’ve developed a robust, cross-linked, chromatin shearing protocol for yeast samples, to be used prior to immunoprecipitation. Our protocol makes use of the Covaris E210, a Focused-ultrasonicator that is high throughput and decreases the probability of contamination relative to the Branson Digital Sonifier.
(Application Notes )
Magnetic Bead-based Purification of Circulating Cell-Free DNA (cfDNA) on the KingFisher™ Duo Prime Purification System Addendum to Product PN 520221
It is challenging to monitor the health of transplanted organs, particularly with respect to rejection by the host immune system. Because transplanted organs have genomes that are distinct from the recipient’s genome, we used high throughput shotgun sequencing to develop a universal noninvasive approach to monitoring organ health. We analyzed cell-free DNA circulating in the […]
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Covaris provides tools and technologies to improve pre-analytical sample preparation, enable novel drug formulations, and manage compounds in the drug discovery process.