Products and Services
What our Customers are Saying
Adaptive Focused Acoustic® (AFA®) Technology
“The pulsing method suggested by Covaris could be used without modifications. We reached our target 150 bp faster with 3x greater recovery using the pulsing method.”
Johanna Andreas Institut für Hämatopathologie, Hamburg
“The key here was the efficiency in low input DNA. Covaris is not dependent on the concentration of DNA and is highly efficient and accurate even with minute amount of samples (here 50pg of DNA and 15 uL). Enzymatic fragmentation does not work with this very low concentration of DNA. We really appreciate your technology for making our research possible.”
Kazuharu Arakawa, Ph.D.Institute for Advanced Biosciences, Keio University
“AFA has shown to be ideal for our facility as we deal with a very wide range of different sample types from microbial systems through to clinical and environmental. This single technology has been successful at effectively disrupting and solubilising every sample we have given it.”
Dr. David Knight Biological Mass Spectrometry Facility Manager, The University of Manchester
“I love AFA-TUBE. It has the same accuracy and reproducibility I expect from the Covaris microTUBE but is even easier to use and is designed for automation.”
ResearcherNIH
Instruments
“We are very impressed with our Covaris AFA systems. They are professionally designed, easy to use and highly controllable equipment and our LE220-plus is now one of the most essential and highly used systems in our facility.”
Dr. David Knight Biological Mass Spectrometry Facility Manager, The University of Manchester
“The Covaris E220 streamlines sample preparation of FFPE tissue for proteomics, cutting down on the number of sample transfers.”
Dr. J. Chapman Laboratory Director, Memorial Sloan-Kettering
“We tested protein extraction from liver and kidney using AFA and cryoPREP together for an enzyme activity assay. Covaris gave comparable results of tissue re-suspension, total protein quantification and enzyme activity, compared to the in-house method. It offered 1) higher standardization of the process, 2) a significant decrease in the time needed for sample preparation. and 3) a safer sample handling for the operator.”
Biochemistry Scientist Pharma Company
“The M220 is a fantastic machine for making ChIP-seq libraries.”
Dr. Rui Yi Ph.D., The University of Colorado
“cryoPREP has the highest reliability in making nucleic acids accessible in a gentle manner especially in comparison with bead-beating of unfrozen samples”
Dr. Claudia Wylezich Institut für Virusdiagnostik
truXTRAC® FFPE Kits
“In collaboration with Covaris and Omniseq, we automated OmniSeq’s clinical FFPE DNA and RNA co-extraction workflow, improving their scalability and throughput. The combination of Covaris’ AFA technology for extraction and Dynamic Devices Lynx’s ST96 Pipettor with iPAW gripper arm produced complex movements and robust pipetting for when dealing with difficult or variable samples types. This all enabled the workflow to be reproducible and accuracy for the required diagnostic tests.”
Jeff KentDynamic Devices
“By using the Covaris truXTRAC FFPE DNA and RNA kits, OmniSeq testing requires less tissue and results in fewer specimen failures when performing comprehensive genomics profiling on solid tumors.”
Jeff ConroyOmniSeq
“Deparaffinization of FFPE tissue in the Covaris E220 allows us to avoid the use of a xylene in our small laboratory space. Paraffin is efficiently removed from FFPE samples, removing any concerns of clogging columns, contaminating instrumentation or suppressing ionization.”
Dr. J. ChapmanLaboratory Director,Memorial Sloan-Kettering
“Having compared various methods for DNA extraction from FFPE material, we now use Covaris followed by an automated bead-based purification methodology. This has now become a standard practice in our laboratories.”
Manu GuptaUniversity College London
“By using truXTRAC FFPE we were able to move away from xylene-based methods for deparaffinization and tissue re-hydration. Using an ultrasonic method for this step has substantially simplified our workflow and has enabled us to extract high quality DNA and RNA from difficult sample types.”
Sr. ScientistMolecular Pathology Core Facility
“After evaluating numerous FFPE extraction methods, we found that extracting DNA and RNA using truXTRAC FFPE gave us consistently higher yields and quality.”
Principal InvestigatorLeading Cancer Institution
“In the past, we used several methods for DNA extraction and found that the Covaris technique is the most successful, when dealing with FFPE tissue samples. There is a great variability in the pre-analytic phase. If we fail with Covaris, we regard the sample as inadequate for NGS.”
Dr. Stefano PileriHaematopathology Division, European Institute of Oncology, Milan, Italy
truXTRAC cfDNA Kits
“I saw 10x increase in yield with the Covaris kit [truXTRAC cfDNA]. Having never run this instrument/kit before (outside training) I found both to be very straightforward and easy to use.”
Scientist Pharmaceutical Company
“Using 200 μL plasma input I saw -10x increase in yield with the Covaris kit vs a competitor. Having never run this kit or instrument before, I found both to be very straightforward and easy to use with clear protocols. My experience with truXTRAC cfDNA isolation has been very positive.”
ResearcherTop Pharmaceutical Company
Chromatin Shearing
“First off, I am new to your technology, and I cannot be more delighted with the sonication chromatin shearing efficiency and reproducibility that I am seeing! I’ve grown very frustrated over the past 2 years using all kinds of different sonicators, and none of them could give me reproducible results, so thank you!”
Mario CorradoVan Andel Institute
“In past we struggled to get reproducible chromatin shearing to a size range suitable for ChIPseq experiments. However, we were relieved that using the Covaris E220 Focused-ultrasonicator enabled us to optimize a chromatin sample preparation protocol in less than 2 weeks. The fast optimization and high degree of reproducibility in shearing, without day to day or sample to sample variation, has made our scientific life much easier.”
Stefanie Dichtl, PhDMax-Planck-Institut für Biochemie
Covaris provides tools and technologies to improve pre-analytical sample preparation, enable novel drug formulations, and manage compounds in the drug discovery process.
CONTACT
Tel: +1 781-932-3959
Fax: +1 781-932-8705
To place orders: CustomerService@covaris.com
Protocol, method and application support: ApplicationSupport@covaris.com
Service and support for your Covaris instruments and consumables: TechSupport@covaris.com