The Adaptive Focused Acoustics® (AFA®) process employs focused bursts of ultrasonic acoustic energy at a frequency 15 to 30 times higher than a sonicator. The very high frequency produces a wavelength of only a few millimeters which enables the ultrasonic acoustic energy to be focused into a discrete zone within a sample vessel immersed in a water bath. Focused-ultrasonicators utilizing AFA technology are highly controllable and may be independently programmed for the power intensity, duration, and duty factor of these bursts. The versatility in power settings supports a wide variety of applications, from gentle mixing to DNA shearing, tissue disruption, and compound management including dissolution, formulation, and emulsification. These acoustic processes are performed in an isothermal, non-contact environment – the water bath maintains sample temperature, and only acoustic energy enters the sample vessel.
Focused-ultrasonicators utilizing AFA technology use acoustic energy to mechanically process samples. When an acoustic burst is applied to the focal zone, numerous cavitation bubbles are generated within the sample. When each acoustic burst is ended, these microscopic bubbles collapse, creating intense, localized, high-velocity jets of solute (typically water). This process is repeated thousands of times per second, promoting rapid processing of sample vessel contents.
Multiple transducer configurations enable single-sample or parallel processing of multiple samples in the acoustic focal zone.
Regardless of the application, Focused-ultrasonicators utilizing AFA technology provide broad programmability and precise control of acoustic burst parameters, providing consistent and reproducible results in a non-contact, isothermal environment.
The AFA acoustic process
Transducer and Transducer with focused acoustic beam shown