Covaris Consumable Shears DNA to 6kbp – 20kbp Fragments

g-TUBE, the latest innovation from Covaris, is a single-use consumable that enables scientists to shear genomic DNA into selected fragments sizes ranging from 6kbp to 20kbp. The only equipment needed is a compatible bench-top centrifuge and a pipette.

g-TUBE uses centrifugal force (the “g” in g-TUBE) to push the sample through a precisely manufactured orifice in the embedded ruby. This produces shearing forces in the sample that fragment the DNA. Fragment size is selected by adjusting the centrifuge rotor speed which alters the flow rate through the ruby and thus the shearing forces. Higher centrifugation RPM will produce shorter fragments and the protocol provide by Covaris contains the settings needed to select a fragment size between 6kbp and 20kbp.

Remarkably, the entire process takes only 3 minutes and up to 24 samples can be processed simultaneously.

Covaris now offers a complete range of products covering all sequencing needs from 100 bp to 20 kbp and consolidates its status as the DNA shearing gold standard.

For additional information, please contact:
Brian Paras
Covaris Inc.
14 Gill St Unit H.
Woburn, Massachusetts, USA 01801
bparas@covaris.com
001 781 932 3959 ext 206

Covaris to Supply the BGI with High-Throughput DNA Shearing for Next-Generation Sequencing

Beijing, China and Woburn, Massachusetts, USA—July 11, 2011—BGI (Beijing Genomics Institute) and Covaris, Inc. today announced a deal that will integrate Covaris’ Adaptive Focused Acoustics™ AFA™ DNA shearing technology across several BGI laboratories in China. BGI will utilize the Covaris LE220 parallel processing, multi-sample platform to fragment DNA samples for Next-Generation Sequencing.

“BGI will use Covaris instrumentation and consumables in our DNA library construction process. Our laboratories will process a large volume of samples on a daily basis, so the multi-sample format provided by the LE220 was a key consideration for us,” said Mr. Zongze Wu, Technical Engineer, DNA Library Construction Group at BGI. “The Covaris LE220 instrument offers both high-throughput capability and consistent high-quality results for our downstream applications”.

“Beijing Genomics Institute is a recognized world leader in the field of genomic research, and Covaris is delighted to be working together with BGI to provide researchers with high-throughput Next Generation sample preparation.” said Jim Laugharn, Covaris President and CEO. “High quality, reproducible sample preparation is the critical first step in improving down-stream analytical results. The unique and highly controlled Covaris systems set the standard for today’s rapidly advancing analytical technologies and sophisticated assays. For example, isothermal Covaris processes will be beneficial for proteomic-related studies such as ChIP”.

About LE220
The award winning LE220 high-performance focused ultra-sonicator is specifically designed for high-throughput operations (such as the Next-Gen Sequencing at BGI) that require high quality DNA shearing. The LE220 utilizes patented AFA technology to concurrently shear multiple DNA samples. AFA technology from Covaris improves recoveries, increases efficiency, and provides high-quality reproducible DNA shearing results.

About BGI
BGI (www.genomics.cn) was founded in Beijing on Sept 9th, 1999 with the mission of supporting the development of science and technology, building strong research teams, and promoting the development of scientific partnership in the genomics field. BGI has created a unique research center with industrialized infrastructure to support innovative development and applications. Sticking to principles of good faith and social responsibility, BGI has made substantial contributions in the fight against SARS and aided in disaster relief for the tsunami in Southeast Asia, all of which greatly enhanced the international reputation of China. Throughout its short history, BGI has created an institutional structure that is characterized by systematization and innovation, institutional integration, technological platform development, and product commercialization. This collaborative system, all of which is powered by the study of genomics, enables BGI to rapidly move from basic research to application.

About Covaris
Covaris, Inc. (www.covaris.com) provides advanced sample preparation systems for life and analytical science. Covaris sample prep technologies support a wide variety of applications including Next-Generation Sequencing, ChIP, proteomics, formulations, and compound management. Our patented Adaptive Focused Acoustic™ (AFA™) technology is the industry standard for DNA shearing, and is used by major genome centers and academic institutions worldwide. AFA brings unsurpassed speed and efficiency to biological and chemical sample preparation. The AFA process, which is based on shock wave physics, delivers controlled, precise, and accurate acoustic energy to biological and chemical samples.

For additional information, please contact:
Brian Paras
Covaris Inc.
14 Gill St Unit H.
Woburn, Massachusetts, USA 01801
bparas@covaris.com
001 781 932 3959 ext 206

Covaris Introduces Bench-top, AFA-based Process Technology

Ground-breaking, enabling tool for both formulation of poorly soluble medias and new drug delivery systems.

Woburn, MA—March 25, 2011—Covaris Incorporated today announced the introduction of the Bench-top SF220 High Performance Formulation Processing System.

The SF220 system was designed to extend the company’s groundbreaking Adaptive Focused Acoustics (AFA) technology to higher volume sample processing. With the ability to process sample volumes from microliters through tens of liters, larger volume application areas such as Pre-clinical formulation, drug delivery systems, and biological processes (such as cell lysis, sonoporation, or transfection) can now “scale-up” the advantages of the proven AFA technology.

The Covaris SF220 system provides a solution for the problem of poorly soluble API’s using the proprietary Covaris AFA Technology. For example, adoption of the AFA-based SF220 system for preparation of DMPK formulations has been shown to improve quality of the studies by increasing the bioavailability, while reducing subjective content and improving operational efficiency. Using AFA to accelerate dissolution can improve both the quality and efficiency of the drug development process, with unparalleled reproducibility, precision, and speed. Demonstrated increases of solubility of over 90% have been achieved, while concurrently reducing the process time from over 2 days of stirring to under 3 minutes, and increasing the available API by over 2.5x due to a dramatic reduction in API degradation. According to Jim Laugharn, Founder and CEO “We at Covaris are very excited about the introduction of the new systems to meet the “pent-up demand” our current customers have for processing larger sample volumes with AFA technology.” At present, Covaris has installed over 1,500 systems in over 30 countries worldwide.

AFA has also been demonstrated to formulate monodisperse, nano-emulsions with mean particle sizes of 20nm and an index below 0.100. Liposomes can be produced using a simple lipid/water combination with the resulting single populations below 100nm. The ability to reduce particle size of a crystalline API in water to below 15nm is possible. All results were achieved using Adaptive Focused Acoustics TM (AFA) with very fast process times, non contact, and isothermal operating conditions.

The Bench-top scale SF220 system is currently available from Covaris. Pilot scale systems are currently in development.

About Covaris, Inc.
Covaris, Inc. is a rapidly growing life science instrument company. Its proprietary instrument platform, based on patented Adaptive Focused Acoustic (AFA) technology brings unsurpassed speed and efficiency to biological and chemical sample preparation. The AFA process, based on shock wave physics, delivers controlled, precise and accurate energy to biological and chemical samples. The process is non-contact, isothermal and rapid. Leading pharmaceutical and biotechnology companies worldwide are using Covaris instruments for DNA shearing, RNA extraction, Compound Dissolution and much more.

Information about Covaris is available at https://www.covaris.com.

Contact:
Carl Beckett
General Manager, Flow Division
Covaris, Inc.
14 Gill Street, Unit H
Woburn, Massachusetts
USA 01801-1721
Tel: +1 781-932-3959 ext 231
Fax: +1 781-932-8705
e-mail: cbeckett@covaris.com
web: www.covaris.com

Caliper And Covaris Establish Co-Marketing Agreement To Simplify Next Generation Sequencing

– Integration of DNA shearing technology with automation and microfluidics solutions simplifies next generation sequencing workflows and improves sample quality –

HOPKINTON, Mass.—Feb. 23, 2011 /PRNewswire/—Caliper Life Sciences, Inc. (CALP: 6.64 -0.15 -2.21%) and Covaris Inc., Woburn, Mass., today announced a co-marketing agreement which will leverage Covaris’ acoustic DNA shearing platforms and Caliper’s automation and microfluidics technologies to develop automated workflows for next generation sequencing experiments. Caliper has developed a complete suite of solutions for library construction, sample analysis, and nucleic acid fractionation, which significantly reduces manual manipulations, increases throughput and improves sample-to-sample consistency.

“Our Sciclone NGS, LabChip GX, and LabChip XT have become critical tools in leading next generation sequencing laboratories already utilizing Covaris’ technology,” said Kevin Hrusovsky, President and Chief Executive Officer of Caliper Life Sciences. “This collaboration is a logical next step toward simplifying workflows for scientists challenged with meeting the growing demands of next generation sequencing sample preparation. As sequencing technologies move from the lab bench to the clinic, it is critical that integrated solutions offer consistency and sample tracking.”

“Covaris provides a wide variety of next-gen sample prep solutions for the evolving needs of sequencing laboratories relative to nucleic acid shearing and sample extraction,” said Jim Laugharn, Covaris President and Chief Executive Officer. “Covaris recognizes the importance of high quality sample preparation as a fundamental component for advanced life science systems, such as in Next Generation DNA Sequencing.”

Covaris sample preparation technology, which is based on its industry-standard Adaptive Focused Acoustic™ (AFA) technology, brings quality, speed, and efficiency to biological and chemical sample preparation with the single-sample S220, the multi-sample E220 and high throughput parallel-processing LE220. The isothermal and non-contact Covaris method accelerates next-generation DNA sequencing sample preparation by providing a highly predictable and reproducible DNA shearing instrumentation, consumables, and applications to the next-gen workflow.

Caliper’s portfolio of microfluidic and automation solutions that uniquely enable sample preparation for high throughput sequencing. Caliper’s sequencing tools include the LabChip XT for nucleic acid fractionation, the LabChip GX for library quantification and sizing, the recently launched LabChip DS for purity and quality control, the Zephyr® Genomics Workstation for automated nucleic acid extraction and reaction setup, and the Sciclone® NGS Workstation, which includes validated protocols for library preparation, sequence capture, and sample normalization. For additional information on Caliper’s solutions for next generation sequencing, please visit www.caliperls.com/genomics.

About Caliper Life Sciences
Caliper Life Sciences is a premier provider of cutting-edge technologies enabling researchers in the life sciences industry to create life-saving and enhancing medicines and diagnostic tests more quickly and efficiently. Caliper is aggressively innovating new technology to bridge the gap between in vitro assays and in vivo results and then translating those results into cures for human disease. Caliper’s portfolio of offerings includes state-of-the-art microfluidics, lab automation & liquid handling, optical imaging technologies, and discovery & development outsourcing solutions.

For more information please visit http://www.caliperLS.com.

About Covaris, Inc.
Covaris, Inc. provides advanced sample preparation systems for life and analytical science. Our sample prep technologies support a wide variety of applications including next-generation DNA sequencing, ChIP, proteomics, and compound management. Our patented Adaptive Focused Acoustic (AFA) technology enables a high energy density to bring unsurpassed speed and efficiency to biological and chemical sample preparation. The AFA process, based on shock wave physics, delivers controlled, precise, and accurate energy to biological and chemical samples.

Information about Covaris is available at https://www.covaris.com.

Caliper, LabChip XT, LabChip GX, LabChip DS, Zephyr and Sciclone are registered trademarks of Caliper Life Sciences, Inc. Covaris, S220, E220, LE220 and Adaptive Focused Acoustics are registered trademarks of Covaris, Inc.

SOURCE Caliper Life Sciences, Inc.

Covaris Receives the Society for Laboratory Automation and Screening (SLAS) New Product Award at LabAutomation 2011

WOBURN, MA—February 8, 2011—The Covaris® LE220™ Focused-ultrasonicator has received the prestigious SLAS New Product Award at the LabAutomation 2011 conference in Palm Springs CA. With over 4,400 attendees, LabAuto is the premier laboratory automation conference and exhibition, bringing science, technology, and industry together.

Breakthrough products introduced at LabAutomation are evaluated by a team of industry experts. Each year, the best and most promising new products are recognized with the SLAS New Product Award. Covaris is very pleased to announce that for 2011, the LE220 is a recipient of the New Product Award designation.

The LE220 was chosen for the New Product Award from more than 400 LabAutomation 2011 exhibitors, based on its technical originality, anticipated impact on the field of laboratory automation, supporting data that reflects universal scientific methodology, and market demand. According to Jim Laugharn, Founder and CEO, “The NPA award is significant recognition and is an affirmation that the patented, controlled AFA physicochemical process is indeed a unique technology platform. This award also reflects the increasing importance of sample preparation as a fundamental component of advanced life science systems, such as in Next Generation DNA Sequencing.”

The LE220 Ultra-sonicator
The LE220 is specifically designed for high-throughput, parallel-processing operations utilizing the Covaris Adaptive Focused Acoustic™ (AFA™) technology. The LE220 is ideal for next-gen nucleic acid sequencing, compound dissolution, tissue/cell lysis applications, and other high-throughput applications. With DNA shearing performance characteristics matching industry-standard Covaris S-series and E-series instruments, the LE220 reproducibly shears DNA to desired lengths, in a multi-sample parallel-processing mode. The LE220 is designed to improve sample processing throughput 8 fold over single sample methods in a 96 tube format (32 fold in a 384 well format).

About Covaris, Inc.
Covaris, Inc. provides advanced sample preparation systems for life and analytical science. Our sample prep technologies support a wide variety of applications including next-generation DNA sequencing, ChIP, proteomics, and compound management. Our patented Adaptive Focused Acoustic (AFA) technology enables a high energy density to bring unsurpassed speed and efficiency to biological and chemical sample preparation. The AFA process, based on shock wave physics, delivers controlled, precise, and accurate energy to biological and chemical samples.

Information about Covaris is available at https://www.covaris.com.

About SLAS
Founded in 1996, SLAS is a worldwide organization providing leadership and educational benefits on the utilization of automation technologies, robotics, and artificial intelligence in order to improve the quality, efficiency, and relevance of laboratory analysis within and across multiple industries. Laboratory Automation includes podium presentations, poster sessions, and exhibiting companies from all over the world showcasing the latest in laboratory automation technologies.

Information about SLAS is available at http://www.slas.org.

Contact:
Brian J. Paras
Director, Strategic Marketing & International Sales
Covaris, Inc.
14 Gill Street, Unit H
Woburn, Massachusetts
USA 01801-1721
bparas@covaris.com
Tel: 001 781.932.3959 ext. 206
web: www.covaris.com