Transitioning from custom amplicon-based parallel sequencing to hybrid capture-based sequencing in molecular pathology routine diagnostics

In this project, a diagnostic custom hybrid capture-based assay was
tested on FFPE material to enable the simultaneous detection of all
genetic alterations and to replace FISH and amplicon-based parallel
sequencing with one assay only. The aim was to translate the new
assay into clinical practice to advance the establishment of targeted
therapies. This will allow rapid, comprehensive and cost-effective
testing for routine molecular pathological diagnostics.