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2012 HUPO Poster- The Yin-Yang of Sample Preparation: Reagent optimization for maximal yield, activity, and preservation of biomarkers using Adaptive Focused Acoustics (AFA)
The Yin-Yang of Sample Preparation: Reagent optimization for maximal yield, activity, and preservation of biomarkers using Adaptive Focused Acoustics (AFA)
A Comparison of Gene Expression Profiles between Glucocorticoid Responder and NonResponder Bovine Trabecular Meshwork Cells Using RNA Sequencing
Bermudez JY, Webber HC, Brown B, Braun TA, Clark AF, Mao W. A Comparison of Gene Expression Profiles between Glucocorticoid Responder and Non-Responder Bovine Trabecular Meshwork Cells Using RNA Sequencing. PLoS ONE. 2017;12(1):e0169671. Abstract: The most common ocular side effect of glucocorticoid (GC) therapy is GC-induced ocular hypertension (OHT) and GC-induced glaucoma (GIG). GC-induced OHT […]
An Integrated Platform for Isolation, Processing, and Mass Spectrometry-based Proteomic Profiling of Rare Cells in Whole Blood
Abstract Isolation and molecular characterization of rare cells (e.g. circulating tumor and stem cells) within biological fluids and tissues has significant potential in clinical diagnostics and personalized medicine. The present work describes an integrated platform of sample procurement, preparation, and analysis for deep proteomic profiling of rare cells in blood. Microfluidic magnetophoretic isolation of target […]
Magrini V, Gao X, Rosa BA, et al. Improving eukaryotic genome annotation using single molecule mRNA sequencing. BMC Genomics. 2018;19(1):172. ABSTRACT: Background The advantages of Pacific Biosciences (PacBio) single-molecule real-time (SMRT) technology include long reads, low systematic bias, and high consensus read accuracy. Here we use these attributes to improve on the genome annotation of […]
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
Sequencing-based DNA methylation profiling methods are comprehensive and, as accuracy and affordability improve, will increasingly supplant microarrays for genome-scale analyses. Here, four sequencing-based methodologies were applied to biological replicates of human embryonic stem cells to compare their CpG coverage genome-wide and in transposons, resolution, cost, concordance and its relationship with CpG density and genomic context.
This document provides users with a complete set of protocols that encompass all Covaris Adaptive Focused Acoustics™ (AFA) instruments for DNA shearing to 150 to 200 bp with 50 to 55 µl of sample volume, to be readily compatible with the Agilent SureSelect Target Enrichment System (XT or XT2). The goal is to provide the most […]
(Application Notes )
The Wellcome Trust Sanger Institute is one of the world’s largest genome centres, and a substantial amount of our sequencing is performed on ‘next generation’ massively parallel sequencing technologies: in June 2008 the quantity of purity filtered sequence data generated by our Genome Analyzer (Illumina) platforms reached 1 terabase, and our average weekly Illumina production […]
Whole-genome resequencing shows numerous genes with nonsynonymous SNPs in the Japanese native cattle Kuchinoshima-Ushi
Because the Japanese native cattle Kuchinoshima-Ushi have been isolated in a small island and their lineage has been intensely protected, it has been assumed to date that numerous and valuable genomic variations are conserved in this cattle breed.
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Covaris provides tools and technologies to improve pre-analytical sample preparation, enable novel drug formulations, and manage compounds in the drug discovery process.