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2012 HUPO Poster- The Yin-Yang of Sample Preparation: Reagent optimization for maximal yield, activity, and preservation of biomarkers using Adaptive Focused Acoustics (AFA)
The Yin-Yang of Sample Preparation: Reagent optimization for maximal yield, activity, and preservation of biomarkers using Adaptive Focused Acoustics (AFA)
Adaptive Focused Acoustic® (AFA) -based sequential RNA and DNA extraction from FFPE tissues using column-based purification PN 520220
Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two-base encoding
We describe the genome sequencing of an anonymous individual of African origin using a novel ligation-based sequencing assay that enables a unique form of error correction that improves the raw accuracy of the aligned reads to >99.9%, allowing us to accurately call SNPs with as few as two reads per allele. We collected several billion […]
Covaris has developed a novel method of active paraffin removal from Formalin-Fixed, Paraffin Embedded (FFPE) tissues utilizing Adaptive Focused Acoustics (AFA) technology. When an AFA treatment is applied to a FFPE sample, the paraffin is separated from the tissue sample by emulsification. This is an active mechanical process eliminating the use of hazardous organic solvents, […]
(Application Notes )
Using next-generation sequencing for high resolution multiplex analysis of copy number variation from nanogram quantities of DNA from formalin-fixed paraffin-embedded specimens
The use of next-generation sequencing technologies to produce genomic copy number data has recently been described. Most approaches, however, reply on optimal starting DNA, and are therefore unsuitable for the analysis of formalin-fixed paraffin-embedded (FFPE) samples, which largely precludes the analysis of many tumour series. We have sought to challenge the limits of this technique […]
Here, we present a general approach for ab initio discovery of the complete transcriptome of the budding yeast, based only on the unannotated genome sequence and millions of short reads from a single massively parallel sequencing run. Using novel algorithms, we automatically construct a highly accurate transcript catalog. Our approach automatically and fully defines 86% […]
AFA-Nanocrystal™ Production Batch-scale (2mL) Cinnarizine (CNZ) Preparation Protocol Part number 010316
Automated NGS Library Construction with Eppendorf epMotion® 5075t/TMX and Covaris® Focused-ultrasonicators
OVERVIEW Next-Generation Sequencing (NGS) platforms require controlled generation of DNA fragments to produce high-quality sequencing data. Covaris leverages its proprietary and patented Adaptive Focused Acoustics (AFA™) technology to convert focused high frequency acoustic energy into mechanical force to randomly fragment nucleic acids in an isothermal and non-contact environment.
(Application Notes )
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Covaris provides tools and technologies to improve pre-analytical sample preparation, enable novel drug formulations, and manage compounds in the drug discovery process.