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Protocol for: Chromatin shearing with non-ionic detergent buffers Part Number 010297
Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture
Genes associated with human microcephaly, a condition characterized by a small brain, include critical regulators of proliferation, cell fate, and DNA repair. We describe a syndrome of congenital microcephaly and diverse defects in cerebral cortical architecture. Genome-wide linkage analysis in two families identified a 7.5 Mb locus on chromosome 19q13.12 containing 148 genes. Targeted high […]
We identified the sequence-specific starting positions of consecutive miscalls in the mapping of reads obtained from the Illumina Genome Analyser (GA). Detailed analysis of the miscall pattern indicated that the underlying mechanism involves sequence-specific interference of the base elongation process during sequencing. The two major sequence patterns that trigger this sequence-specific error (SSE) are: (i) […]
40th Annual Meeting and Exposition of the Controlled Release Society, July 21-24, 2013, Honolulu, Hawaii Schiller, Hanefeld, Schneider, Weigandt, Lehr.
Bind Buffer Safety Data Sheet
(Safety Data Sheets )
Phenobarbital Mediates an Epigenetic Switch at the Constitutive Androstane Receptor (CAR) Target Gene Cyp2b10 in the Liver of B6C3F1 Mice
Here, we evaluate the sensitivity and specificity of genome-wide epigenomic and transcriptomic profiling in phenobarbital (PB)-treated B6C3F1 mice, a well-characterized rodent model of non-genotoxic liver carcinogenesis.
Whole Genome Sequencing Highlights Genetic Changes Associated with Laboratory Domestication of C. elegans
Here we study domestication of the C. elegans Bristol strain as a model, and report the genome sequence of LSJ1 (Bristol), a sibling of the standard C. elegans reference wild type N2 (Bristol). The LSJ1 and N2 lines were cultivated separately from shortly after the Bristol strain was isolated until methods to freeze C. elegans […]
Adaptive Focused Acoustics (AFA) was used to effectively disperse Pseudomonas aeruginosa biofilms and disrupt bacterial cells in a low detergent concentration lysis buffer, significantly increasing the efficiency of protein extraction. Biofilm specific staining with Calcoflour White M2R revealed that overnight cultures of Pseudomonas aeruginosa PA14 produce extensive biofilms, and counterstaining with the cell permeable SYTO […]
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